বৃহস্পতিবার, ২৮ ফেব্রুয়ারী, ২০১৩

PFT: Jets avoided Revis' reps while in Indy

RoethlisbergerGetty Images

Last year, the Steelers cut quarterback Ben Roethlisberger?s base salary from $11.6 million down to the minimum of $900,000.? The $10.7 million became a guaranteed payment, with the cap hit spread equally over the four remaining years in Roethlisberger?s deal.

The move added $2.675 million in cap charges to each year of the contract, pushing this year?s cap number to a belt-bending $19.6 million.

As MDS pointed out earlier in the afternoon, the Steelers plan to do it again, without extending the deal.? But with only three years left on the contract, the Steelers can?t take as large a chunk out of Roethlisberger?s cap number this time around.

Once again, Roethlisberger?s base salary is $11.6 million.? The Steelers could drop it to the 10-year minimum of $940,000.? The $10.66 million difference would then be converted to a guarantee, with the amount spread out over the final three seasons of his contract.

This would create $7.1 million in cap space.? But it also would increase Roethlisberger?s cap number by $3.55 million in 2014 and 2015.? With last year?s restructuring, that?s another $6.225 million to be carried in each of the final two seasons of Roethlisberger?s deal.

And with a base salary of $12.1 million due in 2014, it converts to a minimum cap number of $18.325 million next year.

Whatever the Steelers do, they should wait until March 5 to finalize it.? If they reduce the deal before then, Roethslisberger?s cap number would drop out of the top five in 2013 ? and the exclusive franchise tender the Ravens would have to pay to quarterback Joe Flacco would drop again.

Source: http://profootballtalk.nbcsports.com/2013/02/26/report-jets-avoided-revis-reps-while-in-indy/related/

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USPS Hasn't Paid Insurance Claim After 14 Months, Says ...

It can take months or years of investigation to bring a criminal matter to trial, and complicated insurance matters can often drag on for extended periods of time without resolution. But does the U.S. Postal Service really need more than a year to pay a $30 insurance claim?

That?s the question being asked by a California eBay seller, who shipped a package to a buyer in Italy in Dec. 2011. The package was last tracked by the USPS in New York City, but has long since vanished off the radar. Thankfully, the seller paid for insurance? right?

After all, USPS even told the man that the postal service in Italy had no record of the package being delivered, and the buyer received a refund on his purchase because he says it never arrived.

And yet, in spite of all evidence, USPS rejected his claim, insisting that the package was ?delivered as addressed.?

He tells CBS Sacramento?s Kurtis Ming that he appealed the ruling last year but has heard nothing back from USPS in the eight months since.

?I?m more angry at the system than I am at my money,? the man tells Ming.

In terms of an explanation for the delay, a USPS rep could only say, ?Investigations can take some time? If it didn?t get delivered, and we can prove that it wasn?t delivered, we will honor the claim.?

Source: http://consumerist.com/2013/02/27/usps-hasnt-paid-insurance-claim-after-14-months-says-investigations-take-time/

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বুধবার, ২৭ ফেব্রুয়ারী, ২০১৩

Video: Working moms pan Yahoo CEO?s telecommute ban

Source: http://www.nbcnews.com/id/3041440/vp/50970692#50970692

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Critiquing a Web Site That Tries to Keep It Simple - NYTimes.com

It sounds easy. Sell your product online. Design it to tempt every visitor into becoming a buyer. Add an easy-to-use self-service interface that lets customers get answers without interacting with a salesclerk. Everything seems to happen magically, and everything goes smoothly, without any issues. There may be businesses that manage to accomplish this, but rarely without a few struggles. In this post, we look at one company, Recruiterbox, and its attempt to attract customers and interact with them seemlessly.

Raj Sheth and his two partners created Recruiterbox to help companies organize their recruiting and hiring processes. An entrepreneur from India, Mr. Sheth understood that at many growing companies, the r?sum?s, interviews and internal feedback live ?all over the place,? buried in any number of in-boxes, spreadsheets and side conversations. In 2011, Recruiterbox which is based in Boston and Bangalore and has a team of 12 people, introduced a Web-based tool that automates the entire process. Hiring managers can try the service for free for a single job opening; the fee jumps to $60, $120 or $200 per month for three, six or 10 openings, respectively.

When Recruiterbox was introduced, the company stayed away from outbound marketing like e-mail or telemarketing, opting instead to rely on word-of-mouth, postings to human resources and recruitment blogs and a presence in app stores (like Google Apps). This netted their first 100 or so customers (as well as a few media mentions). Still, attracting visitors to the site was slow, and customer growth, while consistent, remained humble ? in the low hundreds at the end of the first year. In 2012, the customer base grew to 500.

Mr. Sheth has found that he can generate traffic by answering media queries on HelpAReporterOut.com and by crafting frequent blog and video posts that address important H.R. issues. He also has found that including a transcript with the videos helps boost Recruiterbox?s organic search rankings on Google.

Still, revenue grew only slightly after a few months, so Mr. Sheth created a paid Google AdWords campaign. While the quality of customers that came through this channel was high, larger competitors drove up the bids for popular keywords. As a result, each click cost from $7 to $15 ? making AdWords an expensive customer-acquisition channel. The Recruiterbox team kept a fixed budget on their campaign and tweaked the ads, but the cost per paying customer remained high, as much as $500.

After a year, the team began analyzing customer reactions to the sign-up process and pricing structure, which resulted in the company offering more service options. Recruiterbox now handles start-ups and smaller companies ? those with fewer jobs to fill ? through a self-service tool. The site has found that most of the companies that try the service end up completing the 14-day free trial and electing to continue with the monthly subscription.

But Recruiterbox wants to help larger companies, too ? those looking to fill as many as 50 openings. And that?s the challenge: larger clients that want to fill 10 to 25 jobs are much more likely to require an initial service walk-through over the phone to understand how the software works. That of course is a time-consuming burden for a small company.

So the questions facing Mr. Sheth and Recruiterbox are:

Does it make sense for Recruiterbox to focus more attention on one particular customer segment?

? Would concentrating on self-service customers allow Recruiterbox to stick with its original goals and get more business?

? Is that market ? companies with fewer positions to fill ? large enough?

? Should Recruiterbox add more inside sales people to attract and retain larger companies or is that splintering the business focus?

Some questions for readers to think about while looking at Recruiterbox.com:

? Is it easy to understand?

? Can you tell what it?s offering within 15 seconds of landing on the site?

? Would you register without contacting customer support?

? What are your thoughts on tiered service fees?

? Do those fees represent the right value for the cost?

Next week, we?ll follow up with highlights from your comments and I?ll offer my own impressions along with Mr. Sheth?s response.

Would you like to have your business?s Web site or mobile app reviewed? This is an opportunity for companies looking for an honest (and free) appraisal of their online presence and marketing efforts.

To be considered, please tell us ?about your experiences ? why you started your site, what works, what doesn?t and why you would like to have the site reviewed ? in an e-mail to youretheboss@abesmarket.com.

Richard Demb is co-founder of Abe?s Market, an online marketplace for natural products that is based in Chicago.

Source: http://boss.blogs.nytimes.com/2013/02/26/a-web-site-tries-to-keep-it-simple/

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Sony shipping NEX-3N and Alpha A58 to the US in April

Sony shipping NEX3N and Alpha A58 to the US in April

Sony may have teased American photographers by launching the NEX-3N and Alpha A58 in Europe, but it's not cruel: both interchangeable lens cameras are coming to the US this April. The NEX-3N will cost a relatively frugal $500 when bundled with the camera's signature motorized, 16-50mm f/3.5-5.6 lens. Venturing into DSLR territory with the Alpha A58 will cost an only somewhat dearer $600 when paired with a refreshed 18-55mm, f/3.5-5.6 kit lens that's quieter and less error-prone than its ancestor.

Both A- and E-mount cameras will also be getting a similar raft of accessories for the US unveiling. An RM-VPR1 remote commander comes in April for $65, while a compact HVL-F20M flash is due in May for $150. A-series photographers will have no shortage of lenses to choose from -- they'll get cracks at both a stand-alone version of the 18-55mm lens and a new 50mm f/1.4 prime in May for respective prices of $220 and $1,500, while a 70-400mm f/4-5.6 telephoto zoom is coming in July for an eye-watering $2,200.

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Source: http://www.engadget.com/2013/02/25/sony-shipping-nex-3n-and-alpha-a58-to-the-us-in-april/

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মঙ্গলবার, ২৬ ফেব্রুয়ারী, ২০১৩

What's cooking? Just ask Pippa

LONDON (Reuters) - Pippa Middleton, the sister of the Duchess of Cambridge, is to give cooking tips to the masses in a new column for British supermarket chain Waitrose.

Middleton, 29, will write a column for the upmarket chain's monthly magazine, Waitrose Kitchen, called "Pippa's Friday Night Feasts".

Her foray into kitchen advice comes after she released a book called "Celebrate" last year, which was a guide to entertaining through the year and built on the experience she gained working for her family's party-planning business.

The book by the sister of Britain's future queen was both praised and pilloried in equal measure but did not sell well and was quickly discounted in book stores.

William Sitwell, editor of Waitrose Kitchen, said readers would enjoy Middleton's relaxed and easy entertaining ideas.

"Pippa will be an excellent contributor to the magazine, bringing with her a wealth of experience of entertaining, gained in part from working at her family's party business," he said in a statement.

Her first column will appear in the magazine's April issue and will feature casual dining ideas and recipes.

Middleton said her column would be an "exciting opportunity to share my own passion and enthusiasm for food and entertaining and I can't wait to get started".

(Reporting by Belinda Goldsmith; Editing by Michael Roddy)

Source: http://news.yahoo.com/pippa-middleton-write-cookery-column-uk-supermarket-191053248.html

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সোমবার, ২৫ ফেব্রুয়ারী, ২০১৩

Scientists find bone-marrow environment that helps produce infection-fighting T and B cells

Feb. 24, 2013 ? The Children's Medical Center Research Institute at UT Southwestern has deepened the understanding of the environment within bone marrow that nurtures stem cells, this time identifying the biological setting for specialized blood-forming cells that produce the infection-fighting white blood cells known as T cells and B cells.

The research found that cells called early lymphoid progenitors, which are responsible for producing T cells and B cells, thrive in an environment known as an osteoblastic niche. The investigation, published online February 24 in Nature and led by Dr. Sean Morrison, also establishes a promising approach for scientists to map the entire blood-forming system.

Scientists already know how to manufacture large quantities of stem cells that give rise to the nervous system, skin, and other tissues. But they have been unable to make blood-forming stem cells in a laboratory, in part because of a lack of understanding about the niche in which blood-forming stem cells and other progenitor cells reside in the body.

"We believe this research moves us one step closer toward the development of cell therapies in the blood-forming system that don't exist today," said Dr. Morrison, Director of the Institute and Professor of Pediatrics at UT Southwestern Medical Center. "In understanding the environments for blood-forming stem cells and those of different kinds of progenitor cells, we can work toward reproducing those environments in the lab and growing cells that can be transplanted to treat a host of medical conditions."

These findings eventually may help increase the safety and effectiveness of bone-marrow transplants, such as those needed after healthy marrow is destroyed by radiation or chemotherapy treatments for childhood leukemia, Dr. Morrison said. The findings also may have implications for treating illnesses associated with loss of infection-fighting cells, such as HIV and severe combined immunodeficiency disease, better known as bubble boy disease.

The Nature study augments earlier work by Dr. Morrison and his team that showed endothelial cells and perivascular cells lining the blood vessels in the bone marrow create the environment that maintains haematopoietic stem cells, which produce billions of new blood cells every day. The latest study shows that bone-forming cells create the environment that maintains early lymphoid progenitors.

"Our research documents that there are different niches, or microenvironments, for blood-forming stem cells and restricted progenitors in the bone marrow," Dr. Morrison said. "One way that bone marrow makes different kinds of blood-forming cells is by compartmentalizing them into different neighborhoods within the marrow."

The researchers identified niches for stem cells and early lymphoid progenitors by determining which cells are the sources of a growth factor (CXCL12) necessary for the proliferation of those two populations of blood-forming cells. By taking the same approach for other growth factors in the bone marrow, researchers should be able to map the niches for every kind of blood-forming progenitor cell in the bone marrow, Dr. Morrison said.

The UTSW paper's first author is Dr. Lei Ding, a former postdoctoral research fellow at the Children's Research Institute and the Howard Hughes Medical Institute (HHMI) at UT Southwestern. Dr. Ding is now an assistant professor at Columbia University.

Research support came from the HHMI and the National Heart, Lung, and Blood Institute.

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Story Source:

The above story is reprinted from materials provided by UT Southwestern Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lei Ding, Sean J. Morrison. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature, 2013; DOI: 10.1038/nature11885

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/IFzoJpE0Wvk/130224142913.htm

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Huge explosion rattles Syrian capital

DAMASCUS, Syria (AP) ? Damascus residents and state-run TV say a huge explosion has shaken the city.

The blast followed by heavy gunfire caused panic in the capital, where a massive car bombing on Thursday near the ruling Baath party headquarters killed at least 53 people.

It was not immediately clear what the target of Monday's explosion was and whether there were casualties.

State-run TV reported a "terrorist" explosion at the entrance to the northeastern neighborhood of Qaboun.

Source: http://news.yahoo.com/huge-explosion-rattles-syrian-capital-193800452.html

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New maps depict potential worldwide coral bleaching by 2056

Feb. 25, 2013 ? In a study published February 24 in Nature Climate Change researchers used the latest emissions scenarios and climate models to show how varying levels of carbon emissions are likely to result in more frequent and severe coral bleaching events.

Large-scale 'mass' bleaching events on coral reefs are caused by higher-than-normal sea temperatures. High temperatures make light toxic to the algae that reside within the corals. The algae, called 'zooxanthellae', provide food and give corals their bright colors. When the algae are expelled or retained but in low densities, the corals can starve and eventually die. Bleaching events caused a reported 16 percent loss of the world's coral reefs in 1998 according to the Global Coral Reef Monitoring Network.

If carbon emissions stay on the current path most of the world's coral reefs (74 percent) are projected to experience coral bleaching conditions annually by 2045, results of the study show. The study used climate model ensembles from the upcoming Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC).

Around a quarter of coral reefs are likely to experience bleaching events annually five or more years earlier than the median year, and these reefs in northwestern Australia, Papau New Guinea, and some equatorial Pacific islands like Tokelau, may require urgent attention, researchers warn.

"Coral reefs in parts of the western Indian Ocean, French Polynesia and the southern Great Barrier Reef, have been identified as temporary refugia from rising sea surface temperatures," said Ruben van Hooidonk, Ph.D., from the Cooperative Institute for Marine and Atmospheric Studies (CIMAS) at the University of Miami and NOAA's Atlantic Oceanographic and Meteorological Laboratory. "These locations are not projected to experience bleaching events annually until five or more years later than the median year of 2040, with one reef location in the Austral Islands of French Polynesia protected from the onset of annual coral bleaching conditions until 2056."

The findings emphasize that without significant reductions in emissions most coral reefs are at risk, according to the study. A reduction of carbon emissions would delay annual bleaching events more than two decades in nearly a quarter (23 percent) of the world's reef areas, the research shows.

"Our projections indicate that nearly all coral reef locations would experience annual bleaching later than 2040 under scenarios with lower greenhouse gas emissions." said Jeffrey Maynard, Ph.D., from the Centre de Recherches Insulaires et Observatoire de l'Environnement (CRIOBE) in Moorea, French Polynesia. "For 394 reef locations (of 1707 used in the study) this amounts to at least two more decades in which some reefs might conceivably be able to improve their capacity to adapt to the projected changes."

"More so than any result to date, this highlights and quantifies the potential benefits for reefs of reducing emissions in terms of reduced exposure to stressful reef temperatures."

"This study represents the most up-to-date understanding of spatial variability in the effects of rising temperatures on coral reefs on a global scale," said researcher Serge Planes, Ph.D., also from the French research institute CRIOBE in French Polynesia.

The researchers involved in the study all concur that projections that combine the threats posed to reefs by increases in sea temperature and ocean acidification will further resolve where temporary refugia may exist.

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The above story is reprinted from materials provided by University of Miami Rosenstiel School of Marine & Atmospheric Science, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. R. van Hooidonk, J. A. Maynard, S. Planes. Temporary refugia for coral reefs in a warming world. Nature Climate Change, 2013; DOI: 10.1038/nclimate1829

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/qPqev71g7Fs/130225122045.htm

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Police name suspect in Vegas shooting

(Reuters) - Police have identified a suspect in the fatal shooting of an aspiring rapper as he drove on the Las Vegas Strip in a Maserati before dawn on Thursday, sparking a fiery crash that also killed a cab driver and his passenger.

Ammar Asim Faruq Harris, described as armed and dangerous, was still at large on Saturday, but the black Range Rover from which he is suspected of opening fire had been impounded, Las Vegas police said.

Authorities said a gunman in a Range Rover opened fire early on Thursday on the silver Maserati being driven by 27-year-old Kenneth Wayne Cherry Jr., who performed under the name "Kenny Clutch."

Cherry was slain and his car veered out of control and smashed into a taxi, which exploded into flames in an intersection on the Las Vegas Strip in front of several casino resorts, killing the driver and a passenger and triggering another multi-car crash.

Authorities believe the confrontation started in the valet parking lot of a nearby hotel, the Aria Resort and Casino. But police did not identify a motive for the shooting or the altercation.

Police identified Harris, 26, as the driver of the apparently brand-new luxury sport utility vehicle, and said he had also opened fire. Police said in a statement that he had an "extensive and violent criminal history."

Killed in the cab were driver Michael Bolden, 62, and a passenger who has not been identified by authorities. Las Vegas television station KTNV identified the passenger killed as Sandi Sutton, a Washington state woman who worked for a Seattle-area chamber of commerce.

A passenger in Cherry's vehicle suffered a minor injury and cooperated with police, authorities said. Three other people were also injured in the melee, which took place near the Bellagio and Caesars Palace hotels.

The incident occurred less than a mile from where rapper Tupac Shakur was shot in September 1996 while riding in a BMW with Death Row Records co-founder Marion "Suge" Knight after the two men had attended a Mike Tyson boxing match.

Shakur, 25, was hit by gunfire from at least one assailant in a Cadillac while sitting in Knight's car at the intersection of Flamingo Road and Koval Lane and died six days later at a hospital. His murder remains unsolved.

(Reporting by Karen Brooks in Austin, Texas; Editing by Cynthia Johnston and Peter Cooney)

Source: http://news.yahoo.com/suspect-named-las-vegas-shooting-killed-aspiring-rapper-035036806.html

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Switched On: Moving forward with leaning back

Each week Ross Rubin contributes Switched On, a column about consumer technology.

DNP Switched On Moving forward with leaning back

Just a few months have passed between the introduction of the Droid DNA and the new HTC One, but it seems that HTC has been turned upside down in that time. While the Droid DNA was introduced in conjunction with Verizon and can't be a wholly representative picture of how HTC might have introduced the device otherwise, it was a spec- and design-driven product -- a 5-inch, 1080p display with a 440-ppi density that appeared to spill over onto sides that included a microperforation.

In contrast, little was said about the HTC One hardware itself until later in the device's introduction, surprising because the HTC One is not only the most attractive handset the company has ever built, but also certainly one of the most attractive on the market. While it is an Android device, the casing builds upon the tapered, Windows Phone-inspired 8X, substituting aluminum for polycarbonate. That said, there is also the spillover glass effect found on the Droid DNA. The HTC One retains the 1080p display found in the Droid DNA. However, since the screen is smaller, the pixel density is even higher (468 ppi) than in that record-breaking device.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/BFUis8zvHPQ/

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রবিবার, ২৪ ফেব্রুয়ারী, ২০১৩

Dozens of stars spend Saturday at Oscar rehearsals

Actress Catherine Zeta-Jones attends rehearsals for the 85th Academy Awards in Los Angeles, Saturday, Feb. 23, 2013. The Academy Awards are scheduled for Sunday, Feb. 24, 2013. (Photo by Matt Sayles/Invision/AP)

Actress Catherine Zeta-Jones attends rehearsals for the 85th Academy Awards in Los Angeles, Saturday, Feb. 23, 2013. The Academy Awards are scheduled for Sunday, Feb. 24, 2013. (Photo by Matt Sayles/Invision/AP)

In this Feb. 22, 2013, photo, actor Hugh Jackman appears during rehearsals for the 85th Academy Awards in Los Angeles. The Academy Awards are scheduled for Sunday, Feb. 24, 2013. (Photo by Matt Sayles/Invision/AP)

Actor John Travolta attends rehearsals for the 85th Academy Awards in Los Angeles, Saturday, Feb. 23, 2013. The Academy Awards are scheduled for Sunday, Feb. 24, 2013. (Photo by Matt Sayles/Invision/AP)

Actors Chris Pine, left, and Zoe Saldana watch rehearsals for the 85th Academy Awards in Los Angeles, Saturday, Feb. 23, 2013. The Academy Awards will be held Sunday, Feb. 24, 2013. (Photo by Matt Sayles/Invision/AP)

Actress Kerry Washington, left, laughs while talking to Hawk Koch, president of The Academy of Motion Picture Arts and Sciences, during rehearsals for the 85th Academy Awards in Los Angeles, Saturday, Feb. 23, 2013. The Academy Awards are scheduled for Sunday, Feb. 24, 2013. (Photo by Matt Sayles/Invision/AP)

(AP) ? Some dressed down in jeans and hoodies. Others looked camera-ready in suits or chic dresses and spiky stilettos.

But all of the stars who rehearsed Saturday for the 85th Academy Awards seemed excited about being a part of the big show.

They paraded through the Dolby Theatre in 15-minute increments: Meryl Streep. Ben Affleck. Reese Witherspoon. Richard Gere. Jennifer Aniston. John Travolta. Nicole Kidman. Jack Nicholson. And dozens more.

Each practiced their lines in front of an audience of show workers and awarded prop Oscars to rehearsal actors. They also scanned the theater from the stage, searching for their show-night seats.

"Oh, wow. That's a very dramatic picture of me," best-actress nominee Jessica Chastain said after spotting her seat-saving placard. "I'm looking at everyone's headshots. It's kind of incredible."

Affleck confessed his excitement from the stage as he looked out at all the famous faces expected Sunday.

"This is like the most memorable aspect of the Oscars," the "Argo" director said. "You see all these place cards (at rehearsal), then you come back and they're all here!"

Affleck also chatted backstage with the college students who won a contest to serve as trophy carriers during the ceremony.

"I love that," he said. "It's super cool."

Travolta also took time with the students.

"I was there when that idea was born and I said it was the best idea they could possibly come up with," he told the aspiring filmmakers backstage. "And here you are!"

Travolta plans to bring his 13-year-old daughter, Ella Bleu, to the ceremony.

Kidman made rehearsals a family affair. Husband Keith Urban and their eldest daughter, Sunday, watched from the audience as Kidman ran through her lines.

She looked impeccable in a wine-colored dress and tall, metallic shoes, but other stars were decidedly more casual. Kristen Stewart arrived in jeans, sneakers and a backward ballcap. (She also limped on an injured right foot.) Renee Zellweger also opted for comfort in jeans and running shoes.

The cast of "Chicago," including Gere, Zellweger, Queen Latifah and Catherine Zeta-Jones, injected their rehearsal with silliness. Latifah purposely over-enunciated her lines, and when a pair of rehearsal actors claimed an Oscar onstage and gave an acceptance speech, Zeta-Jones started to play them off with an imaginary violin.

"Get outta here!" Gere said with a smile.

Octavia Spencer, who won the supporting actress Oscar last year for her performance in "The Help," also had a little fun.

"I'm going to do a soft-shoe," she said, shuffling off stage.

Streep and Jane Fonda were each wowed by the set design. Fonda snapped a photo of it with her iPhone, and Streep marveled at how far the walk to the microphone was.

"All the way to here?!" she asked. "Oh my God."

Halle Berry literally stumbled during her first rehearsal, her pointy heel catching on part of the stage. She insisted on trying again.

"Woo hoo," she said. "Made it."

___

AP Entertainment Writer Sandy Cohen is on Twitter: www.twitter.com/APSandy .

___

Online:

www.oscars.org

Jane Fonda even took a picture of the stage with her iPhone.

The Academy Awards will be presented Sunday and broadcast live on ABC.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-24-Oscar%20Countdown-Stars%20in%20Sneakers/id-66c3c8abef3c4f0282f8d788a7be045d

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Tiny tweezers and their big influence on bustling proteins: Scientists investigate molecular 'clothespins'

Feb. 22, 2013 ? Tiny molecular tweezers have a remarkable impact on bustling proteins: Three research groups from the University of Duisburg-Essen (UDE), the Chemical Genomics Centre of the Max Planck Society in Dortmund and the Max Planck Institut f?r Kohlenforschung in M?lheim found that the molecular tweezers designed by Professor Frank Kl?rner at the UDE can be used to regulate protein -- protein interactions by selectively trapping certain residues of the protein -- and stick like a clothespin.

The research groups of Thomas Schrader (UDE), Christian Ottmann (Chemical Genomics Centre) and Elsa Sanchez Garcia (MPI f?r Kohlenforschung) believe that this might be a promising approach for applications in medical research, as the water soluble tweezers act without inducing toxicity or explicit side effects.

The scientists have tested their small tweezers on proteins that have influence on many processes in the human body. "We also wanted to know how they work," says Dr. Elsa Sanchez Garcia, leader of a Max Planck research group at the Max Planck Institut f?r Kohlenforschung. The chemists have found out that although their tweezers prefer to bind at the amino acid lysine, the protein surrounding of the lysine influences the trapping of the tweezers. Thus, with computer simulations Dr. Sanchez Garcia and her colleague Kenny Bravo Rodriguez have shown which type of lysine the tweezers prefer -- and why that is the case. Their work also allowed to lay down rules for predicting the behavior of the tweezers in the presence of proteins with several lysine residues.

Although the tweezers research is at early stages, their potentiality makes it worth for medical researchers to have a closer look at these results. The 14-3-3 adapter proteins (14-3-3) that the scientists used for their experiments are small recognition proteins that influence many physiological processes by binding their targets via short peptide sequences and modulating their function. For instance, they are able to stabilize certain tumor suppressors. Because of their important role in many biological processes, 14-3-3 proteins are prospective therapeutic agents against severe disorders, such as cancer.

The three research groups published their findings in the Nature Chemistry.

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Story Source:

The above story is reprinted from materials provided by Max-Planck-Institut f?r Kohlenforschung.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. David Bier, Rolf Rose, Kenny Bravo-Rodriguez, Maria Bartel, Juan Manuel Ramirez-Anguita, Som Dutt, Constanze Wilch, Frank-Gerrit Kl?rner, Elsa Sanchez-Garcia, Thomas Schrader, Christian Ottmann. Molecular tweezers modulate 14-3-3 protein?protein interactions. Nature Chemistry, 2013; 5 (3): 234 DOI: 10.1038/nchem.1570

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/zFmxxgQoyMo/130222102648.htm

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Friday Highlights: Judge grants Einhorn's bid to block Apple proxy vote, more in our Apple/Macintosh, and Finances sections; Fortune's Allan Sloan believes Apple could learn from Progressive, a company with "an intelligent, rational, and transparent way to deal with the surplus cash that its operations generate. Apple doesn't"; and Douglas McIntyre calls Apple's board "weak" and problematic in leading the company through times of crisis; Morgan Stanley sat down with Apple CFO, Peter Oppenheimer, came "away more confident" that a low-cost iPhone is in the works; patent lawsuit against Apple targets OS X server, iCloud; Mactuts+ presents their complete guide to the Mac App Store; Macworld explores the sharing features on your Mac, also explains emergency backups you may not know you already have; Macs in Chemistry walks through various offsite backup options you have; smart connected device market being fought out between Apple, Samsung; Apple supplier in China faces fines for polluting local river; MacNewsWorld on the iWatch patent(s) greasing gears of concept designers; iOS 6.1.3 coming soon, said to fix passcode bug; Primate Labs benchmarks the new Retina MacBook Pro, Gizmag compares the new Chromebook Pixel and MacBook Air; Crave shows photo differences between the new HTC One and iPhone 5; TidBITS reviews Mailbox for iPhone; Peter Cohan at Forbes discusses "Apple's innovation problem"; what does Apple fanboy M.G. Siegler think of Google Chromebook Pixel?; James Kostohryz asks whether Apple will exist in 3 years, and if so, what will be its worth?

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"Are Apple's China Problems Over?" Wall St. Cheat Sheet 1:53 PM
  • "Apple Pulls Controversial Proxy Proposal After Court Ruling"?AllThingsD?7:11 PM
  • "Apple yanks proxy proposal after judge backs Einhorn: The company removes a proposal that would eliminate its ability to issue 'blank check' preferred stock without investor approval."?CNET News?8:12 PM
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  • "Greenlight Wins Bid to Block Apple Shareholder Vote: Video"?Bloomberg?3:49 PM
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  • "Essential Mac management tools: If you're trying to add Macs to a fleet of Windows machines, you'll want to check out these offerings" [Slideshow]?InfoWorld?11:38 AM
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  • "Weather Tab Pro available on the Mac App Store, already Top 10"?prMac?8:05 AM
  • "Mac Apps: iAntivirus, TextWrangler, Chrome, Freeway"?FairerPlatform?7:53 AM
  • "These Are the Bacteria Lurking on Your Phone"?Gizmodo?7:44 AM
  • "Apple's App Store, iTunes back online after outages: The company's online services all seem to be back in business now after hit by outages yesterday."?CNET News?8:42 AM
  • "Samsung and Apple Slugging It Out in the Smart Connected Devices Market"?AllThingsD?9:53 AM
  • "'Post-PC Era' Predicted By Steve Jobs Taking Hold as Samsung Tops Apple in Connected Device Market"?MacRumors?9:43 AM
  • "Samsung has overtaken Apple in 'smart connected devices'"?Fortune?10:30 AM
  • "Tablets Take Off In 2012 According To Millennial, With Kindle Fire And iPad Mini Seeing Rapid Growth"?TechCrunch?7:49 AM
  • "Chart of the day: Apple tops Samsung in mobile ad share"?Fortune?8:11 AM
  • "Apple supplier penalized for polluting nearby river in China: Apple is investigating the incident, according to an environmental group"?Computerworld?8:11 AM
  • "Apple supplier faces sanctions over pollution"?Financial Times [Paid Membership Required]?9:19 AM
  • "Microsoft cooler than before, but Apple on top"?Reuters?12:15 PM
  • "LG ad riffs on Apple's panorama commercial, and expands on it"?AppleInsider?9:35 AM
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  • "Ferrari edges out Apple to become world's most powerful brand"?Digital Trends?1:06 PM
  • "NYPD forms dedicated team to catch thieves who steal iPhones and iPads"?New York Post?10:56 AM
  • "Apple now working with NYPD to curb iPhone thefts"?Network World?10:56 AM
  • "NYPD creates special team to recover stolen Apple devices"?CNET News?9:27 PM
  • "How a dedicated team of NYPD cops work with Apple to catch iDevice thieves, even in other countries"?9 to 5 Mac?10:30 AM
  • "NYPD Team Working With Apple to Catch iPhone, iPad Thieves"?PC Magazine?11:53 AM
  • "NYPD And Apple Team Up To Stop iThing Theft In NYC"?TechCrunch?1:00 PM
  • "Locked iPhone Sales Challenged in Hong Kong"?WSJ.com [Paid Membership Required]?7:50 AM
  • "iPhone Deflects Bullet, Saves Soldier's Life"?MacTrast?7:14 PM
  • "Free iOS MLB app update charges users $125.00"?ZDNet?12:52 PM
Non-Apple News
  • "Hacktivists Prep For International Open Data Day"?InformationWeek?12:56 PM
  • "Sony's PS4 future lies in the cloud"?CNNMoney?12:46 PM
  • "New video games mirror debates about data privacy, hacking"?Washington Post [Free Registration Required]?12:35 PM
  • "No touch screen, no keyboard: enter Airwriting"?TG Daily?12:23 PM
  • "Facebook engineers identify Graph Search's big data challenges"?IDG News Service?11:56 AM
  • "Facebook to put old, rarely viewed photos into 'cold storage'"?NBC News?11:46 AM
  • "Austrian research team develop a new flat, flexible, transparent, and potentially disposable polymer sheet for capturing images"?DigiTimes?10:49 AM
  • "Taiwan PC industry at a critical moment: An interview with Wistron chairman"?DigiTimes?10:48 AM
  • "'Star Trek'-like tricorder available soon"?USA Today?10:46 AM
  • "North Korea to offer mobile internet access"?BBC?10:24 AM
  • "LivesOn: New Service to Let You Tweet When You're Dead"?ABCNews?10:23 AM
  • "Amid Hacking Headaches, Twitter Begins Using Email Authentication"?FOXBusiness?11:10 AM
  • "Google buildings exposed to toxic vapors left by chipmakers"?CNET News?12:55 PM
  • "Google adds fee-based support services for cloud platform customers: Users of products like App Engine, Compute Engine and Big Query will be able to purchase access to a variety of technical support services"?IDG News Service?11:57 AM
  • "Chrome 25 Adds Voice Support, Devs Get App Launcher"?PC Magazine?11:52 AM
  • "Google patches Chrome browser, bans stealth add-ons"?PCWorld?11:55 AM
  • "Conan can't resist making an ass of Google Glass"?CNET News?10:12 AM
  • "Nokia to fight rivals with cheaper models -sources"?Reuters?10:06 AM
  • "Samsung Wants to Be a Media Giant. Meet the Guy in Charge of Getting Them There."?AllThingsD?12:51 PM
  • "Samsung Copies the BlackBerry Playbook"?WSJ.com [Paid Membership Required]?9:43 AM
  • "Combes Named to Lead Alcatel-Lucent Through Troubled Time"?New York Times [Free/Paid Registration Required]?10:15 AM
Publications/Podcasts
  • "Gene Steinberg meets tech writer Kirk McElhearn, and Laptop magazine's Avram Piltch, this week on The Tech Night Owl LIVE!"?The Tech Night Owl LIVE?7:07 PM
  • "An Apple watch, PS4, security and bug fixes, cheap iPhone and slippers"?Insanely Great Mac?12:52 PM
  • "New iPad 5 Case Consistent with Rumored Mini-Style Redesign"?MacRumors?9:22 PM
  • "Apple Hiring 'Maps Ground Truth Data Specialist' in Australia"?MacRumors?7:15 PM
  • "iWatch-y Patent Greases the Gears of Concept Designers: There's been much ado about the possibility that an iWatch is in the works, and the buzz was fueled this week by the publication of a patent application Apple filed back in 2011. More than a few renderings of possible designs have been circulating on the Web as well: and one of them in particular seems more Apple-ish than the rest."?MacNewsWorld?9:04 AM
  • "Apple releases iOS 6.1.3 beta with passcode bug fix in tow"?CNET News?9:42 AM
  • "Smartphone by Manufacturer - FixYa Report"?FixYa?2:56 PM
  • "Apple's iPhone Tops Smartphone Reliability Ratings"?ReadWrite?11:40 AM
  • "iPhones are 3X more reliable than Samsung smartphones, Fixya says"?VentureBeat?11:38 AM
  • "Apple v. Samsung: What are the most reliable smartphones on the market?"?ZDNet?12:06 PM
  • "FixYa Study Finds Apple Smartphones to be the Most Reliable"?MacRumors?2:57 PM
  • "Leaked iPad Mini Images Hint at Retina Display"?PC Magazine?11:53 AM
  • "AU Optronics reportedly started mass producing iPad mini 2 Retina panels"?iDownload Blog?4:22 PM
  • "Supposed 2nd-Gen iPad mini Images Surface with Blue Logo"?PadGadget?12:39 PM
  • "GIS expected to bump up touch panel lamination shipments for iPad mini"?DigiTimes?8:09 AM
  • "Is A Retina Display Coming To The MacBook Air In Q3 Of 2013?"?Apple'n'Apps?1:51 PM
  • "Apple working on techniques for presenting sound effects on a portable device"?AppleDailyReport?8:24 AM
Price Trackers/Deals
  • "Doors&Rooms[PLUS] For iPhone and iPad Is Temporarily Available For Free (Normally $0.99)"?Apple Sliced?8:39 AM
  • "Nuclien For iPhone and iPad Is Free Right Now (Previously $0.99)"?Apple Sliced?8:39 AM
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  • "15" MacBook Pro Prices & Sales"?MacPrices?7:53 AM
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  • "MacBook Pro Prices -15 Inch Models -$1,300 to $3,049 -Best Deals, Reviews & Information"?MacReviewZone?7:51 AM
  • "MacBook Pro Prices -13 Inch Models -$1,019 To $2,194 -Best Deals, Reviews & Information"?MacReviewZone?7:51 AM
  • "MacBook Air Prices -$600 To $1,599 -Best Deals, Reviews And Information"?MacReviewZone?7:51 AM
  • "PadGadget Daily App Deal ? 11 iPad Apps on Sale"?PadGadget?9:04 AM
  • "Mac Games: Assassins Creed, $7.49; Civ V, $7.49; More"?FairerPlatform?12:32 PM

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Reviews
  • "Chromebook Pixel vs. MacBook Air"?Gizmag?7:53 AM
  • "HTC One vs iPhone 5 camera duel: Ultrapixel tech tested"?Crave @ CNET?8:11 AM
  • "Which To Choose (Take Two): 27-inch iMac with GTX 675MX GPU? or with GeForce GTX 680MX?"?Bare Feats?12:04 PM
  • "Hands-on: Logitech Bluetooth Easy-Switch Keyboard, Mac, iOS"?Electronista?8:58 AM
  • "Logitech UE Mobile Boombox"?iLounge?3:59 PM
  • "Reviews: Apogee Electronics MiC Studio Quality Microphone"?iLounge?1:53 PM
  • "Four Speck cases for the iPhone 5"?Macworld?1:53 PM
  • "Review: SmartFlex View for iPhone 5"?Macworld?8:51 AM
  • "Review: CandyShell Grip for iPhone 5"?Macworld?8:51 AM
  • "Review: SmartFlex Card for iPhone 5"?Macworld?7:50 AM
  • "Review: Delano Case for iPad Mini, Nexus 7, Kindle Fire, Kindle, And Other 7' Tablet"?Run Around Tech?9:03 AM
iPad/iPhone/iPod touch Apps
  • "Postcardly Postcards for iOS review: Only a few steps, and your postcard is in the mail"?CNET Reviews?8:40 PM
  • "Review: Aerofly FS ? A Realistic, Easy-to-Learn Flight Simulator for iOS"?MacTrast?7:15 PM
  • "Mailbox for iPhone Eases Email Triage but Lacks Key Features"?TidBITS?9:44 AM
  • "Furnish for iOS taps augmented reality to transport IKEA and Crate & Barrel furniture to your home"?The Next Web?8:24 AM
  • "Comparing iPad weather apps at a glance"?iMore?9:22 PM
  • "Built For Entrepreneurs And Investors, Simplr For iPhone Sorts And Prioritizes Your AngelList Feeds"?TechCrunch?12:05 PM
  • "Yahoo updates Flickr iPhone app with tagging, faster uploads, volume shutter and more"?Digital Trends?8:58 AM
  • "Vector Graphics Geeks Will Fall for B?zier ? iPad App Review"?PadGadget?9:05 AM
  • "Met Someone New? Say, 'Hello.' Then, Use iPhone's Evernote Hello To Remember The Details (it's free)"?Mac 360?7:52 AM
  • "Appidemic: Worm Run for iPhone, iPad and iPod touch"?AppleTell?8:56 AM
  • "'Backflip Madness' Review - The Worst Game I Can't Stop Playing"?Touch Arcade?11:41 AM
Tips
  • "Study Smarter ? Take Notes And Highlight Text Within iBooks [iOS Tips]?Cult of Mac?3:02 PM
  • "Automatically backing up photos via cellular data Article"?iLounge?2:58 PM
  • "Apple Loop: Considering iPrefs, Patenting The iWatch, Living In A 'Weird' Post-Jobs World"?Forbes?8:12 PM
  • "iPad problems: What users complain about most"?Digital Trends?7:13 PM
  • "Judge tells Apple and Samsung to narrow their new patent case"?Ars Technica?2:55 PM
  • "Samsung's outrageous VoiceOver suit against Apple stayed in Germany"?iDownload Blog?2:47 PM
  • "The iPad Can Be a True Mac Alternative"?Shawn Blanc?8:08 PM
  • "Why the iPad still can't be a true Mac replacement"?Macworld?12:52 PM
  • "Why I bought a MacBook Air"?ZDNet?12:06 PM
  • "Chromebook Pixel Validates Microsoft's Touch Strategy, Could Force Apple's Hand"?Benzinga Insights?12:02 PM
  • "How China Mobile Could Get the iPhone"?TheStreet?10:57 AM
  • "Grand Theft Apple: killing the console"?Computerworld?10:56 AM
  • "How Apple Is Better At 'Planned Obsolescence' Than Any Other Technology Company"?Mac 360?10:26 AM
  • "Why Every Analyst Is In Love With The Siren Song Of The Low-Cost iPhone"?TechCrunch?10:29 AM
  • "Why An iPhone Mini Is Key For Apple Continuing To Grow"?Cult of Mac?10:19 AM
  • "Apple's Innovation Problem"?Forbes?9:44 AM
  • "More Support For A Low Cost iPhone"?Apple Bitch?9:05 AM
  • "Brazil lawsuit claims iPad 3 made intentionally obsolete"?iDownload Blog?9:03 AM
  • "Will Apple Exist 3 Years From Now? How Much Will It Be Worth?"?Seeking Alpha?8:19 AM
  • "Steve Job's Financial Planning Advice: You Are Already Naked"?Forbes?8:19 AM
  • "Why iOS won't become Apple's 'Windows XP'"?ZDNet?12:06 PM
  • "Risk Averse: Will iOS Become Apple's Windows XP?"?ReadWrite?8:08 AM
  • "Apple Patent For Solar Watch Could Fire Up Stock Again"?Forbes?11:25 AM
  • "Wearable computing devices ? like, say, an 'iWatch,' could exceed 485 million annual shipments by 2018"?AppleDailyReport?8:31 AM
  • "Apple's iWatch Concept Is Real - And Here's How It Might Work"?ReadWrite?8:08 AM
  • "Apple 'slap wrap' patent fuels iWatch rumour"?ZDNet?7:50 AM
Non-Apple
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  • "I miss removable batteries"?ZDNet?12:42 PM
  • "6 ways to speed an old computer"?USA Today?12:31 PM
  • "Even Sony isn't sure what PS4 will look like"?Mashable?12:11 PM
  • "The Hottest Games Coming to Sony's PS4"?PC Magazine?11:50 AM
  • "Review: HP brings sizzle to Windows Storage Server/The HP StoreEasy 5530 puts serious muscle behind Windows file serving, Hyper-V virtualization, and SQL Server workloads"?InfoWorld?11:17 AM
  • "Why you should sign the phone-unlocking petition right now"?InfoWorld?11:16 AM
  • "Hands-on with the Ubuntu Touch Linux smartphone"?InfoWorld?11:16 AM
  • "Where Is The Digital Work Force Growing Fastest?"?Forbes?11:06 AM
  • "Slideshow: Technologies that stood out at 60th ISSCC"?EE Times?10:49 AM
  • "What smartphone feature would you like to see in the future?"?CNN?10:39 AM
  • "Here's what Facebook Graph Search is doing next"?VentureBeat [Free Registration Required]?12:35 PM
  • "How to post to Facebook, Twitter after you die"?CNN?10:39 AM
  • "You Will Subscribe To, Not Buy Software"?BYTE?10:19 AM
  • "Is Republic's $19 cell phone service too good to be true?"?CNET News?10:12 AM
  • "Patent Application Reveals Key Factors In Google News Algorithm"?Forbes?11:07 AM
  • "Hearing Is Believing: People Don'T Realize How Important Great Sound Is Until They Experience It"?BGR?10:16 AM
  • "Sorry, But There'S No Defense For The Chromebook Pixel"?BGR?1:51 PM
  • "Chromebook Pixel hands-on (photos)"?ZDNet?12:41 PM
  • "Get Real, Google. The Pixel Is Too Pricey"?PC Magazine?11:52 AM
  • "Inside Google's ultrabook gambit: With a new laptop, Google is betting that living in the cloud on an ultrabook is not just cheaper, but much better."?Fortune?11:08 AM
  • "Chromebook Pixel: Google takes on Apple"?Telegraph?8:03 AM
Humor/Cartoons
  • "Low Latency No. 52: The waiting game"?CNET News [cartoon]?10:15 AM
  • "Pearls Before Swine"?GoComics?8:12 AM
  • "CEO Whitman: 'We Should Not Break Up' HP" [Video Report]?CNBC?10:01 AM
  • "HP's Whitman vows to keep the company intact, 'on track'"?IDG News Service?11:54 AM
  • "Meg Whitman Wants to Fix and Rebuild HP, Not Break It Up (Video)"?AllThingsD?1:11 PM
  • "H-P Good News Bodes Well for Whitman's Turnaround" [Video Report]?Bloomberg?10:03 AM
  • "HP Investors Heave Sigh of Relief, But Challenges Remain"?TheStreet?9:38 AM
  • "HP Earnings Better Than Feared, but Still Not Great"?AllThingsD?9:51 AM
  • "H-P Analysts Aren't Exactly Jumping on Bullish Bandwagon"?WSJ Blogs?12:34 PM
  • "H-P stock rally not seen since Mark Hurd era: But Meg Whitman's 'better together' gets mixed reviews"?MarketWatch?12:49 PM
  • "HP shares jump after strong results, analysts raise targets"?Reuters?10:01 AM
  • "H-P Shares Rally 8% on Upbeat Guidance"?FOXBusiness?11:10 AM
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