Mar. 5, 2013 ? Among eukaryotes with modified nuclear genetic codes, viruses are unknown. Until now it had been believed that the modifications to the genetic code effectively prevented new viral infections. However, researchers have now reported the first example of a virus that can be shown to have crossed the boundary from organisms using the standard genetic code to those with an alternate genetic code.
"The finding is significant because it means that virus-host co-evolution after a genetic code shift can be more extensive than previously thought," said researcher Derek J. Taylor, professor of biological sciences at the University at Buffalo.
"It shows that these viruses can overcome what appears to be an insurmountable change in the host genome," Taylor said. "So the fact that we haven't previously seen any viruses in these species with a modified genetic code may not be because the viruses can't adapt to that shift. It may be that we haven't looked hard enough."
The study, titled "Virus-host co-evolution under a modified nuclear genetic code," was published on March 5th in PeerJ. The team of scientists, all from the University of Buffalo, discovered the highly adapted virus -- a totivirus -- in the yeast species Scheffersomyces segobiensis (a distant relative of human pathogens in the genus Candida).
In most living things, the genetic code comprises 64 elements called codons, most of which instruct the body to produce a certain amino acid, the basic building block of a protein. In S. segobiensis, however, the genetic code has been modified -- a codon that usually stands for the amino acid leucine codes instead for serine (an amino acid change that can affect how proteins function). It had been thought that such a radical change in the genome may help host species evade viruses.
However, the presence of the totivirus in S. segobiensis shows that viruses may be more nimble than previously thought, able to overcome even this enormous hurdle. Intriguingly, the totivirus the researchers discovered has only one C-U-G codon left in its genome, suggesting that it may have purged that sequence as it adapted to the yeast host.
The research team found other odd and interesting evidence pointing to a history of co-evolution between totiviruses and yeasts with the modified code. For instance, the modified yeasts appeared to have incorporated genetic material from totiviruses into their genomes on at least four occasions. In total, evidence was found of past, or present, viral infection in five lineages of yeasts with a modified genetic code.
In the yeast Scheffersomyces stipitis, the scientists even identified a former totivirus gene that the host is now using to produce a protein.
"It's a non-retroviral RNA virus gene being kidnapped and expressed as a protein by a cellular host in the absence of a current viral infection" Taylor said. The function of this protein is unknown, but the result is further evidence of the unexpected co-evolution between viruses and hosts with modified nuclear code.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by PeerJ, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Derek J. Taylor, Matthew J. Ballinger, Shaun M. Bowman, Jeremy?A. Bruenn. Virus-host co-evolution under a modified nuclear genetic code. PeerJ, 2013; 1: e50 DOI: 10.7717/peerj.50
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/1rLgEXa-SwY/130305080747.htm
Stevie J mothers day 2012 cinco de mayo osama bin laden death spinal muscular atrophy brooklyn nets may day protests
কোন মন্তব্য নেই:
একটি মন্তব্য পোস্ট করুন